Overexpression of mitochondrial ferritin affects the JAK2/STAT5 pathway in K562 cells and causes mitochondria iron accumulation
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منابع مشابه
Over-expression of mitochondrial ferritin affects the JAK2/STAT5 pathway in K562 cells and causes mitochondrial iron accumulation.
BACKGROUND Mitochondrial ferritin is a nuclear encoded iron-storage protein localized in mitochondria. It has anti-oxidant properties related to its ferroxidase activity, and it is able to sequester iron avidly into the organelle. The protein has a tissue-specific pattern of expression and is also highly expressed in sideroblasts of patients affected by hereditary sideroblastic anemia and by re...
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Iron Metabolism & Its Disorders Over-expression of mitochondrial ferritin affects the JAK2/STAT5 pathway in K562 cells and causes mitochondrial iron accumulation Paolo Santambrogio, Benedetta Gaia Erba, Alessandro Campanella, Anna Cozzi, Vincenza Causarano, Laura Cremonesi, Anna Gallì, Matteo Giovanni Della Porta, Rosangela Invernizzi, and Sonia Levi Myelodysplastic Syndromes Impact of the degr...
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Mitochondrial ferritin (MtFt) is a newly identified H-ferritin-like protein expressed only in mitochondria. Previous studies have shown that its overexpression markedly affects intracellular iron homeostasis and rescues defects caused by frataxin deficiency. To assess how MtFt exerts its function under oxidative stress conditions, MtFt overexpressing cells were treated with tert-butyl-hydropero...
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